{"id":39411,"date":"2026-08-15T11:26:00","date_gmt":"2026-08-15T09:26:00","guid":{"rendered":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/?p=39411"},"modified":"2026-08-15T11:49:11","modified_gmt":"2026-08-15T09:49:11","slug":"entretien-ashleigh-shannon-cnrs-sobstiner-a-vouloir-comprendre-des-details-peut-amener-a-des-surprises","status":"publish","type":"post","link":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/2026\/08\/15\/entretien-ashleigh-shannon-cnrs-sobstiner-a-vouloir-comprendre-des-details-peut-amener-a-des-surprises\/","title":{"rendered":"[Entretien] Ashleigh Shannon, CNRS : \u00ab S\u2019obstiner \u00e0 vouloir comprendre des d\u00e9tails peut amener \u00e0 des surprises \u00bb"},"content":{"rendered":"
\n

La Marseillaise<\/b>\u00a0<\/b>:<\/b> Votre \u00e9tude montre une nouvelle fois <\/b><\/p>\n

que des travaux fondamentaux peuvent ouvrir la voie \u00e0 des applications concr\u00e8tes<\/b>\u00a0<\/b>?<\/b><\/p>\n

Ashleigh Shannon<\/b>\u00a0<\/b>:<\/b> Oui cela illustre \u00e0 merveille que s\u2019obstiner \u00e0 essayer de comprendre ce qui pourrait appara\u00eetre comme des d\u00e9tails peut amener \u00e0 des surprises. Ici, tenter de r\u00e9pondre \u00e0 une question fondamentale sur la mani\u00e8re avec laquelle les enzymes construisent les brins d\u2019ADN et d\u2019ARN am\u00e8ne \u00e0 comprendre comment contourner les d\u00e9fenses de certains virus \u00e0 ARN<\/a> – comme les coronavirus -, et donc \u00e0 peut-\u00eatre un jour avoir des traitements anti-viraux efficaces.<\/p>\n

Comment<\/b>\u00a0<\/b>?<\/b><\/p>\n

A.S.<\/b>\u00a0<\/b>:<\/b> Gr\u00e2ce \u00e0 des analogues de nucl\u00e9otides. C\u2019est une famille importante de m\u00e9dicaments anti-viraux. Ils imitent les nucl\u00e9otides naturels, sont incorpor\u00e9s dans l\u2019ADN ou l\u2019ARN et interrompent la r\u00e9plication du virus. Il en existe des tr\u00e8s efficaces contre l\u2019herp\u00e8s, le VIH et l\u2019h\u00e9patite C. Le prochain d\u00e9fi est de trouver des analogues de nucl\u00e9otides aussi efficaces contre les virus \u00e9mergents que sont la dengue, Ebola, les coronavirus… Contre ces derniers et les ar\u00e9navirus – responsables de la fi\u00e8vre de Lassa – les options actuelles restent limit\u00e9es ou imparfaites.<\/p>\n

\u00c0 cause des exonucl\u00e9ases qui retirent les nucl\u00e9otides modifi\u00e9s que l\u2019on tenterait d\u2019ins\u00e9rer… <\/b><\/p>\n

A.S.<\/b>\u00a0<\/b>: <\/b>Oui, et le fonctionnement de ces enzymes \u00e9tait mal compris. On consid\u00e9rait qu\u2019elles se comportaient comme celles des virus \u00e0 ADN, mais personne ne l\u2019avait v\u00e9rifi\u00e9. Or, celles des virus \u00e0 ARN peuvent se comporter diff\u00e9remment et il y a un moyen de les emp\u00eacher d\u2019agir.<\/p>\n

Propos recueillis par Xavier Boivinet<\/span><\/b><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"La Marseillaise : Votre étude montre une nouvelle fois","protected":false},"author":1,"featured_media":39412,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[1636,6256,1795,10,1687,343,16,1790,1592,416,1058,353,4258,988,2001],"news-destination":[],"news-source":[475],"is_homepage":[],"ta_other":[],"class_list":["post-39411","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-societe","tag-adn","tag-arn","tag-biologie","tag-bouches-du-rhone","tag-chercheurs","tag-entretien","tag-marseille","tag-medicaments","tag-recherche","tag-recherche-scientifique","tag-science","tag-sciences","tag-virus","tag-week-end","tag-weekend","news-source-website"],"_links":{"self":[{"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/posts\/39411","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/comments?post=39411"}],"version-history":[{"count":1,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/posts\/39411\/revisions"}],"predecessor-version":[{"id":39413,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/posts\/39411\/revisions\/39413"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/media\/39412"}],"wp:attachment":[{"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/media?parent=39411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/categories?post=39411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/tags?post=39411"},{"taxonomy":"news-destination","embeddable":true,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/news-destination?post=39411"},{"taxonomy":"news-source","embeddable":true,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/news-source?post=39411"},{"taxonomy":"is_homepage","embeddable":true,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/is_homepage?post=39411"},{"taxonomy":"ta_other","embeddable":true,"href":"https:\/\/euapp01.newsmemory.com\/lamarseillaise\/news\/wp-json\/wp\/v2\/ta_other?post=39411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}